Lab for Clinical &
The Lab for Clinical and Integrative Neuroscience is part of Trinity College Institute for Neuroscience at Trinity College Dublin. Using advanced techniques including brain scanning, electrophysiology, and both invasive and noninvasive neuromodulation, we map how the brain responds to pathological perturbations in an adaptive or maladaptive manner to maintain homeostasis. More specifically, we work to understand the mechanisms of (mal)adaptive plasticity in the brain in different neurological (pain, tinnitus, Parkinson's disease, cognitive impairment) and psychiatric diseases (addiction, OCD, depression).
Our research is based on the idea that the mechanisms of adaptive and maladaptive plasticity fall under a universal construct of hierarchically updating prediction errors in an approximately Bayesian way. This so-called Bayesian brain theory proposes that the brain maintains a predictive internal model and constantly compares it with changing environmental cues. Whenever there is a mismatch between the two, the brain decides whether and how to adjust its model depending on the novelty or salience of the environmental stimulus.
Adaptive plasticity reflects a combination of successful bottom-up compensation and top-down updating of this model. Maladaptive plasticity conversely reflects failure in one or both of these mechanisms, resulting in a constant prediction error.
The reach and extent of the research of the Lab for Clinical and Integrative Neuroscience can only be guaranteed through extensive collaboration with basic neuroscience researchers, engineers, neuroimaging experts and clinicians from non-neurosurgical and neurosurgical fields. We have active collaborations with different labs at Trinity College Dubline as well as several external collaborations. Our external partners include St James`s Hospitel, the Department of Surgical Sciences at the University of Otago in New Zealand, the Department of Otolaryngology at Seoul National University Bundang Hospital in South Korea, as well as various other groups in both Europe and the US.
New Research Paper
Together with Prof. Jae-Jin Song of Soeul National University and Prof. Dirk De Ridder of the University of Otago we were able to show that the effect of tinnitus retraining therapy has an effect on resting state cortical oscillations 6 months after the treament.
Lab for Clinical & Integrative Neuroscience, Institute for Neuroscience & Global Brain Health Institute, Trinity College Dublin © 2019