Lab for Clinical &
The Lab for Clinical and Integrative Neuroscience is part of Trinity College Institute for Neuroscience at Trinity College Dublin. Using advanced techniques including brain scanning, electrophysiology, and both invasive and noninvasive neuromodulation, we map how the brain responds to pathological perturbations in an adaptive or maladaptive manner to maintain homeostasis. More specifically, we work to understand the mechanisms of (mal)adaptive plasticity in the brain in different neurological (pain, tinnitus, Parkinson's disease, cognitive impairment) and psychiatric diseases (addiction, OCD, depression).
Our research is based on the idea that the mechanisms of adaptive and maladaptive plasticity fall under a universal construct of hierarchically updating prediction errors in an approximately Bayesian way. This so-called Bayesian brain theory proposes that the brain maintains a predictive internal model and constantly compares it with changing environmental cues. Whenever there is a mismatch between the two, the brain decides whether and how to adjust its model depending on the novelty or salience of the environmental stimulus.
Adaptive plasticity reflects a combination of successful bottom-up compensation and top-down updating of this model. Maladaptive plasticity conversely reflects failure in one or both of these mechanisms, resulting in a constant prediction error.
The reach and extent of the research of the Lab for Clinical and Integrative Neuroscience can only be guaranteed through extensive collaboration with basic neuroscience researchers, engineers, neuroimaging experts and clinicians from non-neurosurgical and neurosurgical fields. We have active collaborations with different labs at Trinity College Dubline as well as several external collaborations. Our external partners include St James`s Hospitel, the Department of Surgical Sciences at the University of Otago in New Zealand, the Department of Otolaryngology at Seoul National University Bundang Hospital in South Korea, as well as various other groups in both Europe and the US.
New research paper
In a new paper we investigate whether a correlation exists between tinnitus behavioural scores and functional brain connectivity of five resting-state networks comprising the auditory, the default mode, the external control left and right, and the salience network. Our results indicate that alterations of functional interactions between key neural circuits of the brain are not limited to one single network. In particular, tinnitus distress shows a strong correlation with the connectivity pattern within and between the right executive control network and the other four resting-state networks, indicating that tinnitus distress is probably the consequence of a hyperactive attention condition. Among the behavioural scores, the strongest correlation is observed between age and hearing loss, while the tinnitus objective loudness was not correlated with any behavioural scores.
Professor Vanneste has been recognized as a ‘World Expert’ in Tinnitus (top 3) and Hearing Disorders (top 5) by the US-based medical website Expertscape which placed him in the top 0.1% of experts in his field.
Expertscape ranks researchers and clinicians according to the quantity and quality of their publications in the medical literature between 2008 and 2019.
Lab for Clinical & Integrative Neuroscience, Institute for Neuroscience & Global Brain Health Institute, Trinity College Dublin © 2019